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- Downstream signaling events of B Cell Receptor (BCR)
description
Second messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RAS via RasGRP proteins, NF-AT via calcineurin, and AKT via PDK1 (reviewed in Shinohara and Kurosaki 2009, Stone 2006)
external resources
NCBI:1269185
REACTOME:R-HSA-1168372
PUBMED:17052215
PUBMED:19909372
genes
AKT1
,
AKT2
,
BAD
,
BTC
,
CASP9
,
CD19
,
CD28
,
CD80
,
CD86
,
CDKN1A
,
CDKN1B
,
CHUK
,
CREB1
,
HBEGF
,
EGF
,
EGFR
,
ERBB2
,
ERBB3
,
ERBB4
,
EREG
,
FGF1
,
FGF2
,
FGF3
,
FGF4
,
FGF5
,
FGF6
,
FGF7
,
FGF8
,
FGF9
,
FGF10
,
FGFR1
,
FGFR3
,
FGFR2
,
FGFR4
,
FOXO1
,
FOXO3
,
MTOR
,
FYN
,
GAB1
,
GRB2
,
GSK3A
,
GSK3B
,
HGF
,
NRG1
,
NR4A1
,
HRAS
,
IKBKB
,
INS
,
INSR
,
IRS1
,
KIT
,
KRAS
,
LCK
,
MDM2
,
MET
,
KITLG
,
FOXO4
,
MOV10
,
NFKB1
,
NFKBIA
,
NFKBIB
,
NFKBIE
,
NRAS
,
PDGFA
,
PDGFB
,
PDGFRA
,
PDGFRB
,
PDPK1
,
PIK3CA
,
PIK3CB
,
PIK3CD
,
PIK3R1
,
PIK3R2
,
PIP4K2A
,
PPP2CA
,
PPP2CB
,
PPP2R1A
,
PPP2R1B
,
PPP2R5A
,
PPP2R5B
,
PPP2R5C
,
PPP2R5D
,
PPP2R5E
,
PRKCB
,
MAPK1
,
MAPK3
,
PSMA1
,
PSMA2
,
PSMA3
,
PSMA4
,
PSMA5
,
PSMA6
,
PSMA7
,
PSMB1
,
PSMB2
,
PSMB3
,
PSMB4
,
PSMB5
,
PSMB6
,
PSMB7
,
PSMB8
,
PSMB9
,
PSMB10
,
PSMC1
,
PSMC2
,
PSMC3
,
PSMC4
,
PSMC5
,
PSMC6
,
PSMD1
,
PSMD2
,
PSMD3
,
PSMD4
,
PSMD5
,
PSMD7
,
PSMD8
,
PSMD9
,
PSMD10
,
PSMD11
,
PSMD12
,
PSMD13
,
PSME1
,
PSME2
,
PTEN
,
PTPN11
,
REL
,
RELA
,
RPS6KB2
,
RPS27A
,
SKP1
,
SRC
,
MAP3K7
,
TP53
,
TSC2
,
UBA52
,
UBB
,
UBC
,
VAV1
,
SEM1
,
FGF23
,
PIP5K1A
,
PIP5K1B
,
PIP4K2B
,
CUL1
,
PIK3R3
,
IKBKG
,
IRS2
,
FGF18
,
FGF17
,
FGF16
,
IER3
,
BCL10
,
BTRC
,
KL
,
PSMF1
,
NRG2
,
PSMD6
,
FGF19
,
AKT3
,
RASGRP1
,
PSME3
,
PSMD14
,
NRG3
,
FRS2
,
MALT1
,
PHLPP2
,
TNRC6B
,
PSME4
,
PHLPP1
,
FBXW11
,
PIP5K1C
,
RASGRP3
,
FGF20
,
AGO1
,
FGF22
,
AGO2
,
TNRC6A
,
ICOS
,
TRAT1
,
PRR5
,
TNRC6C
,
TRIB3
,
MLST8
,
MAPKAP1
,
PIP4K2C
,
AKT1S1
,
CARD11
,
THEM4
,
PIK3AP1
,
PSMB11
,
PSMA8
,
NRG4
,
KLB
,
AGO3
,
AGO4
,
RICTOR
,
C7orf76
,
LOC100506136
,