description
Second messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RAS via RasGRP proteins, NF-AT via calcineurin, and AKT via PDK1 (reviewed in Shinohara and Kurosaki 2009, Stone 2006)

external resources
NCBI:1269185
REACTOME:R-HSA-1168372
PUBMED:17052215
PUBMED:19909372

genes
AKT1 , AKT2 , BAD , BTC , CASP9 , CD19 , CD28 , CD80 , CD86 , CDKN1A , CDKN1B , CHUK , CREB1 , HBEGF , EGF , EGFR , ERBB2 , ERBB3 , ERBB4 , EREG , FGF1 , FGF2 , FGF3 , FGF4 , FGF5 , FGF6 , FGF7 , FGF8 , FGF9 , FGF10 , FGFR1 , FGFR3 , FGFR2 , FGFR4 , FOXO1 , FOXO3 , MTOR , FYN , GAB1 , GRB2 , GSK3A , GSK3B , HGF , NRG1 , NR4A1 , HRAS , IKBKB , INS , INSR , IRS1 , KIT , KRAS , LCK , MDM2 , MET , KITLG , FOXO4 , MOV10 , NFKB1 , NFKBIA , NFKBIB , NFKBIE , NRAS , PDGFA , PDGFB , PDGFRA , PDGFRB , PDPK1 , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PIP4K2A , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R5A , PPP2R5B , PPP2R5C , PPP2R5D , PPP2R5E , PRKCB , MAPK1 , MAPK3 , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , PTEN , PTPN11 , REL , RELA , RPS6KB2 , RPS27A , SKP1 , SRC , MAP3K7 , TP53 , TSC2 , UBA52 , UBB , UBC , VAV1 , SEM1 , FGF23 , PIP5K1A , PIP5K1B , PIP4K2B , CUL1 , PIK3R3 , IKBKG , IRS2 , FGF18 , FGF17 , FGF16 , IER3 , BCL10 , BTRC , KL , PSMF1 , NRG2 , PSMD6 , FGF19 , AKT3 , RASGRP1 , PSME3 , PSMD14 , NRG3 , FRS2 , MALT1 , PHLPP2 , TNRC6B , PSME4 , PHLPP1 , FBXW11 , PIP5K1C , RASGRP3 , FGF20 , AGO1 , FGF22 , AGO2 , TNRC6A , ICOS , TRAT1 , PRR5 , TNRC6C , TRIB3 , MLST8 , MAPKAP1 , PIP4K2C , AKT1S1 , CARD11 , THEM4 , PIK3AP1 , PSMB11 , PSMA8 , NRG4 , KLB , AGO3 , AGO4 , RICTOR , C7orf76 , LOC100506136 ,