description
DAG and calcium activate protein kinase C beta (PKC-beta, Kochs et al. 1991) which phosphorylates CARMA1 and other proteins (Sommer et al. 2005). Phosphorylated CARMA1 recruits BCL10 and MALT1 to form the CBM complex (Sommer et al. 2005, Tanner et al. 2007) which, in turn, recruits the kinase TAK1 and the IKK complex (Sommer et al. 2005, Shinohara et al. 2005 using chicken cells). TAK1 phosphorylates the IKK-beta subunit, activating it (Wang et al. 2001). The IKK complex then phosphorylates IkB complexed with NF-kappaB dimers in the cytosol (Zandi et al. 1998, Burke et al. 1999, Heilker et al. 1999), resulting in the degradation of IkB (Miyamoto et al. 1994, Traenckner et al. 1994, Alkalay et al. 1995, DiDonato et al. 1995, Li et al. 1995, Lin et al. 1995, Scherer et al. 1995, Chen et al. 1995). NF-kappaB dimers are thereby released and are translocated to the nucleus where they activate transcription (Baeuerle and Baltimore 1988, Blank et al. 1991, Ghosh et al. 2008, Fagerlund et al. 2008)

external resources
NCBI:1269186
REACTOME:R-HSA-1169091
PUBMED:10593898
PUBMED:3129195
PUBMED:7479848
PUBMED:7809113
PUBMED:9721103
PUBMED:18462924
PUBMED:8387275
PUBMED:7628694
PUBMED:7862124
PUBMED:7831327
PUBMED:7575604
PUBMED:16356855
PUBMED:16301747
PUBMED:7957109
PUBMED:11460167
PUBMED:9914500
PUBMED:19066035
PUBMED:17428801
PUBMED:7479976
PUBMED:1756723

genes
CHUK , IKBKB , NFKB1 , NFKBIA , NFKBIB , NFKBIE , PRKCB , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , REL , RELA , RPS27A , SKP1 , MAP3K7 , UBA52 , UBB , UBC , SEM1 , CUL1 , IKBKG , BCL10 , BTRC , PSMF1 , PSMD6 , PSME3 , PSMD14 , MALT1 , PSME4 , FBXW11 , CARD11 , PSMB11 , PSMA8 , C7orf76 , LOC100506136 ,