description
RasGRP1 and RasGRP3 bind diacylglycerol at the plasma membrane (Lorenzo et al. 2001) and are phosphorylated by protein kinase C (Teixeira et al. 2003, Zheng et al. 2005). Phosphorylated RasGRP1 (Roose et al. 2007) and RasGRP3 (Ohba et al. 2000, Yamashita et al. 2000, Rebhun et al. 2000, Lorenzo et al. 2001) then catalyze the exchange of GDP for GTP bound by RAS, thereby activating RAS

external resources
NCBI:1269187
REACTOME:R-HSA-1169092
PUBMED:15657177
PUBMED:12730099
PUBMED:10777492
PUBMED:11221888
PUBMED:10835426
PUBMED:10934204
PUBMED:17283063

genes
HRAS , KRAS , NRAS , RASGRP1 , RASGRP3 ,