description
The PI3K/AKT network is negatively regulated by phosphatases that dephosphorylate PIP3, thus hampering AKT activation

external resources
NCBI:1269191
REACTOME:R-HSA-199418

genes
AKT1 , AKT2 , BTC , CD19 , CD28 , CD80 , CD86 , HBEGF , EGF , EGFR , ERBB2 , ERBB3 , ERBB4 , EREG , FGF1 , FGF2 , FGF3 , FGF4 , FGF5 , FGF6 , FGF7 , FGF8 , FGF9 , FGF10 , FGFR1 , FGFR3 , FGFR2 , FGFR4 , FYN , GAB1 , GRB2 , HGF , NRG1 , INS , INSR , IRS1 , KIT , LCK , MET , KITLG , PDGFA , PDGFB , PDGFRA , PDGFRB , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PIP4K2A , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R5A , PPP2R5B , PPP2R5C , PPP2R5D , PPP2R5E , MAPK1 , MAPK3 , PTEN , PTPN11 , SRC , VAV1 , FGF23 , PIP5K1A , PIP5K1B , PIP4K2B , PIK3R3 , IRS2 , FGF18 , FGF17 , FGF16 , IER3 , KL , NRG2 , FGF19 , AKT3 , NRG3 , FRS2 , PHLPP2 , PHLPP1 , PIP5K1C , FGF20 , FGF22 , ICOS , TRAT1 , TRIB3 , PIP4K2C , THEM4 , PIK3AP1 , NRG4 , KLB ,