description
Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes

external resources
NCBI:83091
KEGG:hsa04912
PUBMED:15080147
PUBMED:15982836
PUBMED:14596811
PUBMED:15613448
PUBMED:12943720
PUBMED:10707049
PUBMED:15350605
PUBMED:12963732

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , ATF4 , CACNA1C , CACNA1D , CACNA1F , CACNA1S , CALM1 , CALM2 , CALM3 , CALML3 , CAMK2A , CAMK2B , CAMK2D , CAMK2G , CDC42 , CGA , MAPK14 , HBEGF , EGFR , ELK1 , PTK2B , FSHB , GNA11 , GNAQ , GNAS , GNRH1 , GNRH2 , GNRHR , GRB2 , HRAS , ITPR1 , ITPR2 , ITPR3 , JUN , KRAS , LHB , MAP3K1 , MAP3K3 , MAP3K4 , MMP2 , MMP14 , NRAS , PLA2G4A , PLCB2 , PLCB3 , PLCB4 , PLD1 , PLD2 , PRKACA , PRKACB , PRKACG , PRKCA , PRKCB , PRKCD , MAPK1 , MAPK3 , MAPK7 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAPK13 , MAP2K1 , MAP2K2 , MAP2K3 , MAP2K6 , MAP2K7 , RAF1 , MAPK12 , MAP2K4 , SOS1 , SOS2 , SRC , PLA2G4C , JMJD7-PLA2G4B , MAP3K2 , PLCB1 , CALML5 , CALML4 , PLA2G4E , CALML6 , ADCY4 , PLA2G4F , PLA2G4D , PLA2G4B ,