description
Major histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular bacteria or tumor-associated antigens. They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell surface. This enables cytotoxic T cells to identify and eliminate cells that are synthesizing abnormal or foreign proteins. MHC class I is a trimeric complex composed of a polymorphic heavy chain (HC or alpha chain) and an invariable light chain, known as beta2-microglobulin (B2M) plus an 8-10 residue peptide ligand. Represented here are the events in the biosynthesis of MHC class I molecules, including generation of antigenic peptides by the ubiquitin/26S-proteasome system, delivery of these peptides to the endoplasmic reticulum (ER), loading of peptides to MHC class I molecules and display of MHC class I complexes on the cell surface

external resources
NCBI:1269192
REACTOME:R-HSA-983169
PUBMED:8717519
PUBMED:17145306
PUBMED:18926908
PUBMED:17055423
PUBMED:12495737
PUBMED:18641646
PUBMED:18243674

genes
B2M , BLMH , BTK , CALR , CANX , CBLB , CCNF , CD14 , CD36 , CDC20 , CDC27 , CDC34 , CHUK , CTSL , CTSV , CTSS , CYBA , CYBB , FCGR1A , FCGR1B , PDIA3 , UBE2K , HLA-A , HLA-B , HLA-C , HLA-E , HLA-F , HLA-G , HLA-H , HSPA5 , IKBKB , ITGAV , ITGB5 , LMO7 , LNPEP , MRC1 , TRIM37 , MYD88 , NCF2 , NCF4 , NEDD4 , PRKN , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , RBBP6 , RNF4 , RNF6 , RPS27A , SEC13 , FBXW4 , SIAH1 , SIAH2 , SKP1 , SKP2 , TRIM21 , STX4 , TAP1 , TAP2 , TAPBP , ELOC , ELOB , TLR1 , TLR2 , TLR4 , TPP2 , UBA52 , UBB , UBC , UBA1 , UBA7 , UBE2A , UBE2B , UBE2D1 , UBE2D2 , UBE2D3 , UBE2E1 , UBE2E2 , UBE2G1 , UBE2G2 , UBE2H , UBE2L3 , UBE2N , UBE2V1 , UBE2V2 , UBE3A , VHL , ZBTB16 , SEM1 , CUL5 , GAN , CUL3 , CUL2 , CUL1 , IKBKG , SOCS1 , VAMP8 , CDC23 , SNAP23 , CDC16 , HERC3 , HERC2 , HERC1 , BTRC , SOCS3 , UBA3 , UBE2M , UBE2L6 , TRIP12 , VAMP3 , UBE4A , PSMF1 , NPEPPS , RNF14 , RNF7 , SEC24C , DZIP3 , UBE3C , DCAF1 , KEAP1 , CUL7 , PSMD6 , PJA2 , AREL1 , SEC24D , MRC2 , KLHL21 , RBX1 , HUWE1 , RNF41 , PSME3 , PSMD14 , STUB1 , TRAIP , KLHL41 , TLR6 , ANAPC10 , UBAC1 , ARIH2 , SEC24B , UBE2E3 , SEC23A , LRRC41 , FBXW10 , ATG7 , RBCK1 , SEC24A , SEC61B , WWP1 , UBE2C , KLHL2 , SEC31A , UBOX5 , TRIM32 , FBXO21 , FBXL7 , PSME4 , FBXW11 , MGRN1 , UBR2 , NEDD4L , UBR4 , UFL1 , SEC61G , MKRN1 , LY96 , FBXO7 , HECTD1 , ANAPC13 , RNF19A , RCHY1 , LTN1 , HERC4 , WSB1 , FBXW2 , FBXL21 , FBXL3 , FBXO2 , FBXL5 , FBXL4 , KLHL3 , FBXW8 , FBXO22 , FBXO10 , FBXO9 , FBXO6 , FBXO4 , RNF115 , KLHL20 , UBE2S , MYLIP , ANAPC2 , SEC61A1 , ANAPC4 , CD207 , KLHL5 , SAR1B , ASB3 , RLIM , HERC5 , MEX3C , FZR1 , ANAPC5 , ANAPC7 , RNF138 , UBE2J1 , ANAPC11 , UBE2D4 , ASB1 , ASB4 , ASB2 , FBXO40 , ERAP1 , BTBD1 , FBXW5 , FBXL19 , RNF111 , FBXL12 , UBE2R2 , HERC6 , DET1 , KLHL11 , SEC61A2 , RNF220 , UBA6 , UBE2W , FBXW7 , FBXL8 , TRIM36 , UBE2Q1 , RNF126 , RNF130 , RNF114 , KLHL9 , TRIM39 , SMURF1 , HECW2 , HACE1 , KLHL42 , SH3RF1 , RNF213 , RNF123 , UBE2O , ERAP2 , PJA1 , RNF25 , KLHL25 , ANAPC1 , UNKL , SMURF2 , UBE2Z , FBXL15 , HECTD3 , ASB13 , FBXO31 , UBA5 , FBXL18 , SPSB1 , RNF34 , TRIM11 , ITCH , KBTBD7 , FBXO30 , TRAF7 , FBXW9 , KBTBD8 , TRIM63 , LNX1 , SPSB2 , KLHL22 , ZNRF1 , FBXL20 , TRIM4 , KBTBD6 , UBE3B , UBE3D , BTBD6 , KLHL13 , LRSAM1 , TRIM41 , LONRF1 , SPSB4 , ASB16 , UBE2Q2 , FBXO44 , TRIM9 , TIRAP , FBXO32 , FBXO17 , UBE2J2 , PSMB11 , LRR1 , FBXO27 , ASB17 , RNF19B , TRIM71 , TRIM50 , ASB10 , ASB11 , ASB5 , ASB6 , ASB7 , ASB8 , ASB9 , TRIM69 , UBE2F , MIB2 , ASB15 , ASB14 , ASB12 , HECTD2 , PSMA8 , FBXL14 , FBXL16 , UBE2U , FBXO41 , DTX3L , RNF217 , KCTD7 , CBLL2 , UBR1 , KCTD6 , FBXO15 , TRIM39-RPP21 , RNF182 , FBXL13 , ZNRF2 , CDC26 , RNF144B , FBXL22 , FBXW12 , KBTBD13 , ASB18 , C7orf76 , NCF1 , LOC100506136 , MIR4720 , MIR5193 ,