description
Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents. The most important positive regulator of melanogenesis is the MC1 receptor with its ligands melanocortic peptides. MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), which produce melanin. Melanin synthesis takes place within specialized intracellular organelles named melanosomes. Melanin-containing melanosomes then move from the perinuclear region to the dendrite tips and are transferred to keratinocytes by a still not well-characterized mechanism

external resources
NCBI:83092
KEGG:hsa04916
PUBMED:11041354
PUBMED:10347209
PUBMED:15016298
PUBMED:11023702
PUBMED:11602344
PUBMED:12753399
PUBMED:10841026
PUBMED:16822996
PUBMED:15383650
PUBMED:9263329
PUBMED:16246839
PUBMED:10643996
PUBMED:12894244

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , ASIP , CALM1 , CALM2 , CALM3 , CALML3 , CAMK2A , CAMK2B , CAMK2D , CAMK2G , CREB1 , CREBBP , CTNNB1 , DCT , DVL1 , DVL2 , DVL3 , EDN1 , EDNRB , EP300 , FZD2 , GNAI1 , GNAI2 , GNAI3 , GNAO1 , GNAQ , GNAS , GSK3B , HRAS , KIT , KRAS , MC1R , KITLG , MITF , NRAS , PLCB2 , PLCB3 , PLCB4 , POMC , PRKACA , PRKACB , PRKACG , PRKCA , PRKCB , PRKCG , MAPK1 , MAPK3 , MAP2K1 , MAP2K2 , RAF1 , TCF7 , TCF7L2 , TYR , TYRP1 , WNT1 , WNT2 , WNT3 , WNT5A , WNT6 , WNT7A , WNT7B , WNT8A , WNT8B , WNT10B , WNT11 , WNT2B , WNT9A , WNT9B , FZD5 , FZD3 , FZD1 , FZD4 , FZD6 , FZD7 , FZD8 , FZD9 , CREB3 , FZD10 , PLCB1 , LEF1 , WNT16 , CALML5 , WNT4 , CREB3L2 , WNT10A , WNT5B , TCF7L1 , CREB3L3 , WNT3A , CREB3L1 , CALML4 , CREB3L4 , CALML6 , ADCY4 ,