description
Mammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of TLR3, can initiate downstream signaling trough MyD88. In the MyD88 - dependent pathway, once the adaptor is bound to TLR it leads to recruitment of IL1 receptor associated kinase family IRAK which is followed by activation of tumour necrosis factor receptor-associated factor 6 (TRAF6) . TRAF6 is an ubiquitin E3 ligase which in turn induces TGF-beta activating kinase 1 (TAK1) auto phosphorylation. Once activated TAK1 can ultimately mediate the induction of the transcription factor NF-kB or the mitogen-activated protein kinases (MAPK), such as JNK, p38 and ERK. This results in the translocation of the activated NF-kB and MAPKs to the nucleus and the initiation of appropriate gene transcription leading to the production of many proinflammatory cytokines and antimicrobial peptides

external resources
NCBI:1269207
REACTOME:R-HSA-975871
PUBMED:15728506
PUBMED:16239509

genes
AGER , APP , ATF1 , CHUK , MAP3K8 , CREB1 , ATF2 , MAPK14 , DHX9 , DUSP3 , DUSP4 , DUSP6 , DUSP7 , ELK1 , FOS , HMGB1 , IKBKB , IRAK1 , IRAK2 , JUN , MEF2A , MEF2C , MAP3K1 , MYD88 , NFKB1 , NFKB2 , NFKBIA , NFKBIB , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R5D , MAPK1 , MAPK3 , MAPK7 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAP2K1 , MAP2K3 , MAP2K6 , MAP2K7 , RELA , RPS6KA1 , RPS6KA2 , RPS6KA3 , RPS27A , S100A12 , S100B , SAA1 , MAP2K4 , SKP1 , MAP3K7 , TLR5 , TRAF6 , UBA52 , UBB , UBC , UBE2N , UBE2V1 , MAPKAPK3 , CUL1 , IKBKG , RIPK2 , BTRC , RPS6KA5 , MAPKAPK2 , NOD1 , TAB1 , TAB2 , FBXW11 , IRAK4 , VRK3 , ECSIT , PELI2 , PELI1 , NOD2 , TNIP2 , TLR10 , PELI3 , TAB3 , MIR718 ,