description
NF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting in dissociation of NF-kappaB from the complex. This allows translocation of NF-kappaB to the nucleus where it regulates gene expression

external resources
NCBI:1269210
REACTOME:R-HSA-445989
PUBMED:15837794
PUBMED:11460167

genes
AGER , APP , CHUK , DHX9 , HMGB1 , IKBKB , IRAK1 , IRAK2 , MYD88 , NFKB1 , NFKB2 , NFKBIA , NFKBIB , RELA , S100A12 , S100B , SAA1 , MAP3K7 , TRAF6 , UBE2N , UBE2V1 , IKBKG , RIPK2 , NOD1 , TAB1 , TAB2 , NOD2 , TAB3 , MIR718 ,