description
MyD88-independent signaling pathway is shared by TLR3 and TLR4 cascades. TIR-domain-containing adapter-inducing interferon-beta (TRIF or TICAM1) is a key adapter molecule in transducing signals from TLR3 and TLR4 in a MyD88-independent manner (Yamamoto M et al. 2003a). TRIF is recruited to ligand-stimulated TLR3 or 4 complex via its TIR domain. TLR3 directly binds TRIF (Oshiumi H et al 2003). In contrast, TLR4-mediated signaling pathway requires two adapter molecules, TRAM (TRIF-related adapter molecule or TICAM2) and TRIF. TRAM(TICAM2) is thought to bridge between the activated TLR4 complex and TRIF (Yamamoto M et al. 2003b, Tanimura N et al. 2008, Kagan LC et al. 2008).TRIF recruitment to TLR complex stimulates distinct pathways leading to production of type 1 interferons (IFNs), pro-inflammatory cytokines and induction of programmed cell death

external resources
NCBI:1269220
REACTOME:R-HSA-166166
PUBMED:15276183

genes
AGER , BIRC2 , BIRC3 , APP , ATF1 , CASP8 , CD14 , CHUK , MAP3K8 , CREB1 , ATF2 , MAPK14 , DHX9 , DUSP3 , DUSP4 , DUSP6 , DUSP7 , ELK1 , FOS , HMGB1 , IKBKB , IRAK1 , IRAK2 , IRF3 , IRF7 , JUN , MEF2A , MEF2C , MYD88 , NFKB1 , NFKB2 , NFKBIA , NFKBIB , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R5D , MAPK1 , MAPK3 , MAPK7 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAP2K1 , MAP2K3 , MAP2K6 , MAP2K7 , PTPN11 , RELA , RPS6KA1 , RPS6KA2 , RPS6KA3 , RPS27A , S100A12 , S100B , SAA1 , MAP2K4 , SKP1 , MAP3K7 , TLR3 , TLR4 , TRAF3 , TRAF6 , UBA52 , UBB , UBC , UBE2D1 , UBE2D2 , UBE2D3 , UBE2N , UBE2V1 , MAPKAPK3 , CUL1 , IKBKG , RIPK1 , RIPK2 , FADD , BTRC , RPS6KA5 , MAPKAPK2 , IKBKE , TANK , NOD1 , TAB1 , RIPK3 , SARM1 , TAB2 , FBXW11 , LY96 , TBK1 , VRK3 , NOD2 , TNIP2 , TICAM1 , TAB3 , TICAM2 , MIR718 ,