description
MyD88-independent signaling pathway is shared by TLR3 and TLR4 cascades. TIR-domain-containing adapter-inducing interferon-beta (TRIF or TICAM1) is a key adapter molecule in transducing signals from TLR3 and TLR4 in a MyD88-independent manner (Yamamoto M et al. 2003a). TRIF is recruited to ligand-stimulated TLR3 or 4 complex via its TIR domain. TLR3 directly binds TRIF (Oshiumi H et al 2003). In contrast, TLR4-mediated signaling pathway requires two adapter molecules, TRAM (TRIF-related adapter molecule or TICAM2) and TRIF. TRAM(TICAM2) is thought to bridge between the activated TLR4 complex and TRIF (Yamamoto M et al. 2003b, Tanimura N et al. 2008, Kagan LC et al. 2008).TRIF recruitment to TLR complex stimulates distinct pathways leading to production of type 1 interferons (IFNs), pro-inflammatory cytokines and induction of programmed cell death
external resources
NCBI:1269220
REACTOME:R-HSA-166166
PUBMED:15276183
genes
AGER
,
BIRC2
,
BIRC3
,
APP
,
ATF1
,
CASP8
,
CD14
,
CHUK
,
MAP3K8
,
CREB1
,
ATF2
,
MAPK14
,
DHX9
,
DUSP3
,
DUSP4
,
DUSP6
,
DUSP7
,
ELK1
,
FOS
,
HMGB1
,
IKBKB
,
IRAK1
,
IRAK2
,
IRF3
,
IRF7
,
JUN
,
MEF2A
,
MEF2C
,
MYD88
,
NFKB1
,
NFKB2
,
NFKBIA
,
NFKBIB
,
PPP2CA
,
PPP2CB
,
PPP2R1A
,
PPP2R1B
,
PPP2R5D
,
MAPK1
,
MAPK3
,
MAPK7
,
MAPK8
,
MAPK11
,
MAPK9
,
MAPK10
,
MAP2K1
,
MAP2K3
,
MAP2K6
,
MAP2K7
,
PTPN11
,
RELA
,
RPS6KA1
,
RPS6KA2
,
RPS6KA3
,
RPS27A
,
S100A12
,
S100B
,
SAA1
,
MAP2K4
,
SKP1
,
MAP3K7
,
TLR3
,
TLR4
,
TRAF3
,
TRAF6
,
UBA52
,
UBB
,
UBC
,
UBE2D1
,
UBE2D2
,
UBE2D3
,
UBE2N
,
UBE2V1
,
MAPKAPK3
,
CUL1
,
IKBKG
,
RIPK1
,
RIPK2
,
FADD
,
BTRC
,
RPS6KA5
,
MAPKAPK2
,
IKBKE
,
TANK
,
NOD1
,
TAB1
,
RIPK3
,
SARM1
,
TAB2
,
FBXW11
,
LY96
,
TBK1
,
VRK3
,
NOD2
,
TNIP2
,
TICAM1
,
TAB3
,
TICAM2
,
MIR718
,
