description
TRIF(TICAM1) was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists of an N-terminal region (1-234), a TIR domain (235-500), and a C-terminal region (501-680). The N-terminal region of TRIF harbors TRAF (TNF receptor associated factor) family proteins and forms complexes containing IRF-3 and/or NFkB -activating kinases. The C-terminal region of TRIF can recruit receptor-interacting protein-1 (RIP-1), and this event is followed by the activation of IKK complex

external resources
NCBI:1269221
REACTOME:R-HSA-937061
PUBMED:15814722
PUBMED:12855817
PUBMED:14739303

genes
AGER , BIRC2 , BIRC3 , APP , ATF1 , CASP8 , CD14 , CHUK , MAP3K8 , CREB1 , ATF2 , MAPK14 , DHX9 , DUSP3 , DUSP4 , DUSP6 , DUSP7 , ELK1 , FOS , HMGB1 , IKBKB , IRAK1 , IRAK2 , IRF3 , IRF7 , JUN , MEF2A , MEF2C , MYD88 , NFKB1 , NFKB2 , NFKBIA , NFKBIB , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R5D , MAPK1 , MAPK3 , MAPK7 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAP2K1 , MAP2K3 , MAP2K6 , MAP2K7 , PTPN11 , RELA , RPS6KA1 , RPS6KA2 , RPS6KA3 , RPS27A , S100A12 , S100B , SAA1 , MAP2K4 , SKP1 , MAP3K7 , TLR3 , TLR4 , TRAF3 , TRAF6 , UBA52 , UBB , UBC , UBE2D1 , UBE2D2 , UBE2D3 , UBE2N , UBE2V1 , MAPKAPK3 , CUL1 , IKBKG , RIPK1 , RIPK2 , FADD , BTRC , RPS6KA5 , MAPKAPK2 , IKBKE , TANK , NOD1 , TAB1 , RIPK3 , SARM1 , TAB2 , FBXW11 , LY96 , TBK1 , VRK3 , NOD2 , TNIP2 , TICAM1 , TAB3 , TICAM2 , MIR718 ,