description
Receptor-interacting protein 1 (RIP1) mediates the activation of proinflammatory cytokines via intermediate induction of IKK complex in NFkB pathways [Ea et al. 2006]. Poly(I-C) treatment stimulated the recruitment of RIP1, TRAF6, and TAK1 to the TLR3 receptor complex in human embryonic kidney HEK293 transfected with FLAG-tagged TLR3 [Cusson-Hermance et al. 2005]. RIP1 was shown to be dispensable for TRIF-dependent activation of IRF3, which occurs in a TRIF/TBK1/IKKi-dependent manner [Cusson-Hermance et al. 2005, Sato et al. 2003

external resources
NCBI:1269223
REACTOME:R-HSA-937041
PUBMED:16603398
PUBMED:16115877
PUBMED:14530355

genes
BIRC2 , BIRC3 , CD14 , CHUK , IKBKB , RPS27A , TLR3 , TLR4 , TRAF6 , UBA52 , UBB , UBC , UBE2D1 , UBE2D2 , UBE2D3 , UBE2N , UBE2V1 , IKBKG , RIPK1 , RIPK3 , SARM1 , LY96 , TICAM1 , TICAM2 ,