description
TLR3 and -4 trigger TRIF-dependent programmed cell death in various human and mouse cells (Kalai M et al. 2002; Han KJ et al. 2004; Kaiser WJ and Offermann MK 2005; Estornes Y et al. 2012; He S et al. 2011). Apoptosis is a prevalent form of programmed cell death and is mediated by the activation of a set of caspases. In addition to apoptosis, TLR3/TLR4 activation induces RIP3-dependent necroptosis. These two programmed cell-death pathways may suppress each other. When the caspase activity is impaired or inhibited, certain cell types switch the apoptotic death program to necroptosis in response to various stimuli (TNF, Fas, viral infection and other stress stimuli) (Kalai M et al. 2002; Weber A et al. 2010; Feoktistova M et al. 2011, Tenev et al 2011)

external resources
NCBI:1269224
REACTOME:R-HSA-2562578
PUBMED:12181749
PUBMED:15814722
PUBMED:20019748
PUBMED:22421964
PUBMED:21737329
PUBMED:14739303
PUBMED:21737330

genes
CASP8 , CD14 , TLR3 , TLR4 , RIPK1 , FADD , RIPK3 , LY96 , TICAM1 , TICAM2 ,