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- MyD88 dependent cascade initiated on endosome
description
Upon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I IFNs
external resources
NCBI:1269228
REACTOME:R-HSA-975155
PUBMED:20237413
PUBMED:15276183
PUBMED:18652679
genes
AGER
,
APP
,
ATF1
,
CD14
,
CHUK
,
MAP3K8
,
CREB1
,
ATF2
,
MAPK14
,
DHX9
,
DUSP3
,
DUSP4
,
DUSP6
,
DUSP7
,
ELK1
,
FOS
,
HMGB1
,
IKBKB
,
IRAK1
,
IRAK2
,
IRF7
,
JUN
,
MEF2A
,
MEF2C
,
MAP3K1
,
MYD88
,
NFKB1
,
NFKB2
,
NFKBIA
,
NFKBIB
,
PPP2CA
,
PPP2CB
,
PPP2R1A
,
PPP2R1B
,
PPP2R5D
,
MAPK1
,
MAPK3
,
MAPK7
,
MAPK8
,
MAPK11
,
MAPK9
,
MAPK10
,
MAP2K1
,
MAP2K3
,
MAP2K6
,
MAP2K7
,
RELA
,
RPS6KA1
,
RPS6KA2
,
RPS6KA3
,
RPS27A
,
S100A12
,
S100B
,
SAA1
,
MAP2K4
,
SKP1
,
MAP3K7
,
TLR3
,
TLR4
,
TRAF6
,
UBA52
,
UBB
,
UBC
,
UBE2N
,
UBE2V1
,
MAPKAPK3
,
CUL1
,
IKBKG
,
RIPK2
,
BTRC
,
RPS6KA5
,
MAPKAPK2
,
NOD1
,
TAB1
,
TAB2
,
FBXW11
,
LY96
,
IRAK4
,
VRK3
,
TLR7
,
ECSIT
,
TLR8
,
TLR9
,
PELI2
,
PELI1
,
NOD2
,
TNIP2
,
TICAM1
,
DHX36
,
PELI3
,
TAB3
,
TICAM2
,
MIR718
,