description
TRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1

external resources
NCBI:1269229
REACTOME:R-HSA-975138
PUBMED:22511786
PUBMED:18794297

genes
AGER , APP , ATF1 , CD14 , CHUK , MAP3K8 , CREB1 , ATF2 , MAPK14 , DHX9 , DUSP3 , DUSP4 , DUSP6 , DUSP7 , ELK1 , FOS , HMGB1 , IKBKB , IRAK1 , IRAK2 , JUN , MEF2A , MEF2C , MAP3K1 , MYD88 , NFKB1 , NFKB2 , NFKBIA , NFKBIB , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R5D , MAPK1 , MAPK3 , MAPK7 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAP2K1 , MAP2K3 , MAP2K6 , MAP2K7 , RELA , RPS6KA1 , RPS6KA2 , RPS6KA3 , RPS27A , S100A12 , S100B , SAA1 , MAP2K4 , SKP1 , MAP3K7 , TLR3 , TLR4 , TRAF6 , UBA52 , UBB , UBC , UBE2N , UBE2V1 , MAPKAPK3 , CUL1 , IKBKG , RIPK2 , BTRC , RPS6KA5 , MAPKAPK2 , NOD1 , TAB1 , TAB2 , FBXW11 , LY96 , IRAK4 , VRK3 , TLR7 , ECSIT , TLR8 , TLR9 , PELI2 , PELI1 , NOD2 , TNIP2 , TICAM1 , PELI3 , TAB3 , TICAM2 , MIR718 ,