description
In plasmacytoid dendritic cell induction of type I IFNs critically depends on IFN regulatory factor 7 in TLR7 and 9 signaling (Honda et al 2005). IRF-7, but not IRF3, interacts with MyD88, TRAF6, and IRAKs and translocates to the nucleus upon phosphorylation (Kawai et al 2004; Uematsu et al 2005). TLR7/8 signaling was shown to induce IRF5 activation along with IRF7 [Schoenemeyer et al 2005], while IRF8 [Tsujimura H et al 2004] and IRF1 were reported to be implicated in TLR9 signaling

external resources
NCBI:1269232
REACTOME:R-HSA-975110
PUBMED:16214811
PUBMED:11070172

genes
IRAK1 , IRF7 , MYD88 , TRAF6 , UBE2N , UBE2V1 , IRAK4 , TLR7 , TLR8 , TLR9 , DHX36 , MIR718 ,