description
IPS-1/MAVS/Cardif/VISA with its TRAF-interaction motif (TIM) directly interacts with TRAF3 and recruits TRAF3 to the RIG-I/MDA5 signaling complex. TRAF3 acts as a scaffold for the assembly of a signaling complex composed of IKK epsilon/TBK1, leading to the activation of transcription factors IRF3/IRF7

external resources
NCBI:1269260
REACTOME:R-HSA-918233
PUBMED:17190786
PUBMED:16306936

genes
CREBBP , EP300 , IFNB1 , IRF3 , IRF7 , TRAF3 , TRIM25 , IKBKE , DDX58 , TBK1 , MAVS , IFIH1 , SIKE1 , RNF135 , MIR1281 , MIR3614 ,