description
Fas-AssociatedDeathDomain (FADD) and receptor interacting protein 1 (RIP1) are death domain containing molecules that interact with the C-terminal portion of IPS-1 and induce NF-kB through interaction and activation of initiator caspases (caspase-8 and -10). Caspases are usually involved in apoptosis and inflammation but they also exhibit nonapoptotic functions. These nonapoptotic caspase functions involve prodomain-mediated activation of NF-kB. Processed caspases (caspase-8/10) encoding the DED (death effector domain) strongly activate NF-kB. The exact mechanism by which caspases mediate NF-kB activation is unclear, but the prodomains of caspase-8/10 may act as a scaffolding and allow the recruitment of the IKK complex in association with other signaling molecules

external resources
NCBI:1269261
REACTOME:R-HSA-933543
PUBMED:16618810
PUBMED:16127453
PUBMED:16585540
PUBMED:12884866

genes
CASP8 , CASP10 , CHUK , IKBKB , TRIM25 , IKBKG , RIPK1 , FADD , DDX58 , MAVS , IFIH1 , RNF135 , MIR3614 ,