The TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in Tool like receptor (TLR) mediated cytokine production, the involvement of these molecules in the regulation of type I IFN induction mediated by RIG-I/MDA5 pathway is largely unknown. According to the study done by Yoshida et al RIG-I/IPS-1 pathway requires TRAF6 and MAP3K, MEKK1 to activate NF-kB and MAP Kinases for optimal induction of type I IFNs

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AGER , APP , CHUK , DHX9 , HMGB1 , IKBKB , MAP3K1 , MYD88 , NFKB1 , NFKB2 , NFKBIA , NFKBIB , RELA , S100A12 , S100B , SAA1 , TRAF2 , TRAF6 , TRIM25 , IKBKG , DDX58 , MAVS , IFIH1 , RNF135 , MIR3614 ,