description
As with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune diseases. RIG-I-mediated production of IFN can, in turn, increase the transcription of RIG-I itself, thus setting into motion an IFN amplification loop, which if left unchecked, could become deleterious to the host. This module mainly focuses on the endogenous negative regulation of the RIG-I-like receptor (RLR) family proteins RIG-I and MDA5

external resources
NCBI:1269264
REACTOME:R-HSA-936440
PUBMED:18703349
PUBMED:18549796

genes
CYLD , UBE2K , IRF3 , PCBP2 , PIN1 , RPS27A , TNFAIP3 , TRAF3 , UBA52 , UBB , UBC , UBA7 , UBE2D1 , UBE2D2 , UBE2D3 , TRIM25 , TAX1BP1 , ATG12 , UBE2L6 , ATG5 , ISG15 , IKBKE , DDX58 , TBK1 , HERC5 , RNF216 , RNF125 , OTUD5 , MAVS , IFIH1 , NLRX1 , ITCH , NLRC5 , RNF135 , MIR3614 , MIR5193 ,