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description
Presence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon (IFN)-regulatory factors (DAI) (also called Z-DNA-binding protein 1, ZBP1), absent in melanoma 2 (AIM2), RNA polymerase III (Pol III), IFN-inducible protein IFI16, leucine-rich repeat flightless interacting protein-1 (LRRFIP1), DEAH-box helicases (DHX9 and DHX36), DEAD-box helicase DDX41, meiotic recombination 11 homolog A (MRE11), DNA-dependent protein kinase (DNA-PK), cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING).Detection of cytosolic DNA requires multiple and possibly redundant sensors leading to activation of the transcription factor NF-kappaB and TBK1-mediated phosphorylation of the transcription factor IRF3. Cytosolic DNA also activates caspase-1-dependent maturation of the pro-inflammatory cytokines interleukin IL-1beta and IL-18. This pathway is mediated by AIM2

external resources
NCBI:1269268
REACTOME:R-HSA-1834949
PUBMED:23706668
PUBMED:21533068
PUBMED:23706667

genes
AGER , APP , POLR3D , CHUK , CREBBP , CTNNB1 , DHX9 , EP300 , XRCC6 , HMGB1 , IFI16 , IKBKB , IRF3 , IRF7 , MRE11 , MYD88 , NFKB1 , NFKB2 , NFKBIA , NFKBIB , POLR2E , POLR2F , POLR2H , POLR2K , POLR2L , PRKDC , RELA , RPS27A , S100A12 , S100B , SAA1 , TRIM21 , STAT6 , TLR3 , UBA52 , UBB , UBC , XRCC5 , IKBKG , RIPK1 , LRRFIP1 , POLR1C , POLR3F , POLR3G , POLR3C , RIPK3 , POLR3A , TREX1 , TRIM32 , DTX4 , CRCP , TBK1 , POLR1D , DDX41 , POLR3K , POLR3B , POLR3E , ZBP1 , TRIM56 , POLR3GL , CGAS , NLRP4 , TICAM1 , DHX36 , POLR3H , NLRC3 , TMEM173 , MIR1281 ,