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- Cytosolic sensors of pathogen-associated DNA
description
Presence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon (IFN)-regulatory factors (DAI) (also called Z-DNA-binding protein 1, ZBP1), absent in melanoma 2 (AIM2), RNA polymerase III (Pol III), IFN-inducible protein IFI16, leucine-rich repeat flightless interacting protein-1 (LRRFIP1), DEAH-box helicases (DHX9 and DHX36), DEAD-box helicase DDX41, meiotic recombination 11 homolog A (MRE11), DNA-dependent protein kinase (DNA-PK), cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING).Detection of cytosolic DNA requires multiple and possibly redundant sensors leading to activation of the transcription factor NF-kappaB and TBK1-mediated phosphorylation of the transcription factor IRF3. Cytosolic DNA also activates caspase-1-dependent maturation of the pro-inflammatory cytokines interleukin IL-1beta and IL-18. This pathway is mediated by AIM2
external resources
NCBI:1269268
REACTOME:R-HSA-1834949
PUBMED:23706668
PUBMED:21533068
PUBMED:23706667
genes
AGER
,
APP
,
POLR3D
,
CHUK
,
CREBBP
,
CTNNB1
,
DHX9
,
EP300
,
XRCC6
,
HMGB1
,
IFI16
,
IKBKB
,
IRF3
,
IRF7
,
MRE11
,
MYD88
,
NFKB1
,
NFKB2
,
NFKBIA
,
NFKBIB
,
POLR2E
,
POLR2F
,
POLR2H
,
POLR2K
,
POLR2L
,
PRKDC
,
RELA
,
RPS27A
,
S100A12
,
S100B
,
SAA1
,
TRIM21
,
STAT6
,
TLR3
,
UBA52
,
UBB
,
UBC
,
XRCC5
,
IKBKG
,
RIPK1
,
LRRFIP1
,
POLR1C
,
POLR3F
,
POLR3G
,
POLR3C
,
RIPK3
,
POLR3A
,
TREX1
,
TRIM32
,
DTX4
,
CRCP
,
TBK1
,
POLR1D
,
DDX41
,
POLR3K
,
POLR3B
,
POLR3E
,
ZBP1
,
TRIM56
,
POLR3GL
,
CGAS
,
NLRP4
,
TICAM1
,
DHX36
,
POLR3H
,
NLRC3
,
TMEM173
,
MIR1281
,