description
Cross-linking of FCGRs with IgG coated immune complexes results in tyrosine phosphorylation of the immuno tyrosine activation motif (ITAMs) of the rececptor by membrane-bound tyrosine kinases of the SRC family. The phosphorylated ITAM tyrosines serve as docking sites for Src homology 2 (SH2) domain-containing SYK kinase. Recruitment and activation of SYK is critical for FCGR-mediated signaling in phagocytosis, but the exact role of SYK in this process is unclear. Activated SYK then transmits downstream signals leading to actin polymerization and particle internalization

external resources
NCBI:1269280
REACTOME:R-HSA-2029481
PUBMED:17050193
PUBMED:12488490
PUBMED:18322649

genes
CD3G , CD247 , FCGR1A , FCGR2A , FCGR3A , FGR , FYN , HCK , IGHG1 , IGHG2 , IGHG3 , IGHG4 , IGLC1 , IGLC6 , LYN , SRC , SYK , YES1 , FCGR2C , IGKV3D-11 , IGKV5-2 , IGKV4-1 ,