description
The actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and CDC42 exert their action through the members of WASP family proteins (WASP/N-WASP/WAVE) and ARP2/3 complex. Actin filaments move from the bottom toward the top of the phagocytic cup during pseudopod extension

external resources
NCBI:1269281
REACTOME:R-HSA-2029482
PUBMED:17477841
PUBMED:15452139
PUBMED:15981459

genes
ABL1 , ACTB , ACTG1 , BTK , CD3G , CD247 , CDC42 , CFL1 , CRK , DOCK1 , FCGR1A , FCGR2A , FCGR3A , GRB2 , NCKAP1L , HSP90AA1 , HSP90AB1 , IGHG1 , IGHG2 , IGHG3 , IGHG4 , IGLC1 , IGLC6 , LIMK1 , MYH2 , MYH9 , MYO1C , MYO5A , MYO9B , MYO10 , NCK1 , PAK1 , MAPK1 , MAPK3 , PTK2 , RAC1 , SYK , VAV1 , VAV2 , WAS , WIPF1 , WASF1 , WASL , FCGR2C , ELMO1 , ABI1 , ARPC5 , ARPC4 , ARPC3 , ARPC1B , ACTR3 , ACTR2 , ARPC2 , ABI2 , WASF2 , VAV3 , BAIAP2 , ARPC1A , NCKAP1 , WASF3 , CYFIP1 , CYFIP2 , IGKV3D-11 , IGKV5-2 , IGKV4-1 , NCKIPSD , BRK1 , ELMO2 , WIPF2 , WIPF3 ,