description
Cholera toxin (CTX) is one of the main virulence factors of Vibrio cholerae. Once secreted, CTX B-chain (CTXB) binds to ganglioside GM1 on the surface of the host's cells. After binding takes place, the entire CTX complex is carried from plasma membrane (PM) to endoplasmic reticulum (ER). In the ER, the A-chain (CTXA) is recognized by protein disulfide isomerase (PDI), unfolded, and delivered to the membrane where the membrane-associated ER-oxidase, Ero1, oxidizes PDI to release the CTXA into the protein-conducting channel, Sec61. CTXA is then retro-translocated to the cytosol and induces water and electrolyte secretion by increasing cAMP levels via adenylate cyclase (AC) to exert toxicity. Other than CTX, Vibrio cholerae generates several toxins that are perilous to eukaryotic cells. Zonula occludens toxin (ZOT) causes tight junction disruption through protein kinase C-dependent actin polymerization. RTX toxin (RtxA) causes actin depolymerization by covalently cross-linking actin monomers into dimers, trimers, and higher multimers. Vibrio cholerae cytolysin (VCC) is an important pore-forming toxin. The assembly of VCC anion channels in cells cause vacuolization and lysis

external resources
NCBI:83101
KEGG:hsa05110
PUBMED:12671039
PUBMED:17464284
PUBMED:17156122
PUBMED:11207565
PUBMED:13679513
PUBMED:11032799
PUBMED:14659695
PUBMED:11953326
PUBMED:10942706
PUBMED:12102686
PUBMED:11349009
PUBMED:11292584
PUBMED:12403808
PUBMED:11454785
PUBMED:15204437

genes
ACTB , ACTG1 , ADCY3 , ADCY9 , ARF1 , ATP6V1A , ATP6V1B1 , ATP6V1B2 , ATP6V0C , ATP6V1C1 , ATP6V1E1 , ATP6V0B , ATP6V1G2 , ATP6V0A1 , ATP6AP1 , CFTR , GNAS , KCNQ1 , MUC2 , PLCG1 , PLCG2 , PRKACA , PRKACB , PRKACG , PRKCA , SLC12A2 , TJP1 , ATP6V0E1 , ATP6V0D1 , ATP6V1F , TJP2 , ATP6V1G1 , PDIA4 , TCIRG1 , KDELR1 , SEC61B , KDELR2 , KDELR3 , SEC61G , ATP6V0A2 , SEC61A1 , ERO1A , ATP6V0A4 , ATP6V1D , ATP6V1H , SEC61A2 , ATP6V1E2 , ATP6V1G3 , ATP6V0E2 , ATP6V0D2 , ATP6V1C2 ,