description
A number of inactive tetrameric PKA holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. When cAMP binds to two specific binding sites on the regulatory subunits, these undergo a conformational change that causes the dissociation of a dimer of regulatory subunits bound to four cAMP from two monomeric, catalytically active PKA subunits

external resources
NCBI:1269295
REACTOME:R-HSA-163615
PUBMED:2165385

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , PRKACA , PRKACB , PRKACG , PRKAR1A , PRKAR1B , PRKAR2A , PRKAR2B , ADCY4 ,