description
CLEC7A (Dectin-1) signals through the classic calcineurin/NFAT pathway through Syk activation phospholipase C-gamma 2 (PLCG2) leading to increased soluble IP3 (inositol trisphosphate). IP3 is able to bind endoplasmic Ca2+ channels, resulting in an influx of Ca2+ into the cytoplasm. This increase in calcium concentration induces calcineurin activation and consequently, dephosphorylation of NFAT and its translocation into the nucleus, triggering gene transcription and extracellular release of Interleukin-2 (Plato et al. 2013, Goodridge et al. 2007, Mourao-Sa et al. 2011)
external resources
NCBI:1269305
REACTOME:R-HSA-5607763
PUBMED:17312158
PUBMED:22611159
PUBMED:21728173
genes
CALM1
,
CALM2
,
CALM3
,
ITPR1
,
ITPR2
,
ITPR3
,
NFATC1
,
NFATC2
,
NFATC3
,
PPP3CA
,
PPP3CB
,
PPP3R1
,
AHCYL1
,
