description
There are several proteins and mechanisms involved in controlling the extent of ligand stimulation of IFNA/B signaling. These mechanisms can effect every step of the IFNA/B cascade. Dephosphorylation of JAK and STAT by SHP protein phosphatases, inhibition of STAT function in the nucleus by protein inhibitors of activated STATs (PIAS) proteins, inhibition of tyrosine kinase activity of JAKs by SOCS as well as inhibition of JAK and IFNAR2 interaction by UBP43 are few of the negative regulation mechanisms in controling type I IFN signaling

external resources
NCBI:1269313
REACTOME:R-HSA-912694
PUBMED:16710296
PUBMED:16311601
PUBMED:10526574

genes
IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 , IFNAR1 , IFNAR2 , IFNB1 , JAK1 , PTPN1 , PTPN6 , PTPN11 , STAT1 , STAT2 , TYK2 , SOCS1 , SOCS3 , USP18 ,