description
The GPVI receptor is a complex of the GPVI protein with Fc epsilon R1 gamma (FcR). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FcR complex in platelets and initiate platelet activation through phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) in the FcR gamma chain, leading to binding and activation of the tyrosine kinase Syk. Downstream of Syk, a series of adapter molecules and effectors lead to platelet activation. The GPVI receptor signaling cascade is similar to that of T- and B-cell immune receptors, involving the formation of a signalosome composed of adapter and effector proteins. At the core of the T-cell receptor signalosome is the transmembrane adapter LAT and two cytosolic adapters SLP-76 and Gads. While LAT is essential for signalling to PLCgamma1 downstream of the T-cell receptor, the absence of LAT in platelets only impairs the activation of PLCgamma2, the response to collagen and GPVI receptor ligands remains sufficient to elicit a full aggregation response. In contrast, GPVI signalling is almost entirely abolished in the absence of SLP-76
external resources
NCBI:1269357
REACTOME:R-HSA-114604
PUBMED:16102042
PUBMED:11943772
genes
AKT1
,
AKT2
,
RHOA
,
RHOB
,
RHOG
,
CDC42
,
CSF2
,
CSF2RA
,
CSF2RB
,
FCER1G
,
FYN
,
GRB2
,
IL2
,
IL2RA
,
IL2RB
,
IL2RG
,
IL3
,
IL3RA
,
IL5
,
IL5RA
,
JAK1
,
JAK2
,
JAK3
,
LCK
,
LCP2
,
LYN
,
PDPK1
,
PIK3CA
,
PIK3CB
,
PIK3CD
,
PIK3CG
,
PIK3R1
,
PIK3R2
,
PLCG2
,
PRKCZ
,
PTPN6
,
PTPN11
,
RAC1
,
RAC2
,
SHC1
,
SYK
,
VAV1
,
VAV2
,
PIK3R3
,
GAB2
,
AKT3
,
VAV3
,
PDPN
,
PIK3R5
,
LAT
,
GP6
,
CLEC1B
,
MPIG6B
,
PIK3R6
,
