description
The GPVI receptor is a complex of the GPVI protein with Fc epsilon R1 gamma (FcR). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FcR complex in platelets and initiate platelet activation through phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) in the FcR gamma chain, leading to binding and activation of the tyrosine kinase Syk. Downstream of Syk, a series of adapter molecules and effectors lead to platelet activation. The GPVI receptor signaling cascade is similar to that of T- and B-cell immune receptors, involving the formation of a signalosome composed of adapter and effector proteins. At the core of the T-cell receptor signalosome is the transmembrane adapter LAT and two cytosolic adapters SLP-76 and Gads. While LAT is essential for signalling to PLCgamma1 downstream of the T-cell receptor, the absence of LAT in platelets only impairs the activation of PLCgamma2, the response to collagen and GPVI receptor ligands remains sufficient to elicit a full aggregation response. In contrast, GPVI signalling is almost entirely abolished in the absence of SLP-76

external resources
NCBI:1269357
REACTOME:R-HSA-114604
PUBMED:16102042
PUBMED:11943772

genes
AKT1 , AKT2 , RHOA , RHOB , RHOG , CDC42 , CSF2 , CSF2RA , CSF2RB , FCER1G , FYN , GRB2 , IL2 , IL2RA , IL2RB , IL2RG , IL3 , IL3RA , IL5 , IL5RA , JAK1 , JAK2 , JAK3 , LCK , LCP2 , LYN , PDPK1 , PIK3CA , PIK3CB , PIK3CD , PIK3CG , PIK3R1 , PIK3R2 , PLCG2 , PRKCZ , PTPN6 , PTPN11 , RAC1 , RAC2 , SHC1 , SYK , VAV1 , VAV2 , PIK3R3 , GAB2 , AKT3 , VAV3 , PDPN , PIK3R5 , LAT , GP6 , CLEC1B , MPIG6B , PIK3R6 ,