description
Hydrolysis of phosphatidyl inositol-bisphosphate (PIP2) by phospholipase C (PLC) produces diacylglycerol (DAG) and inositol triphosphate (IP3). Both are potent second messengers. IP3 diffuses into the cytosol, but as DAG is a hydrophobic lipid it remains within the plasma membrane. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, while DAG activates the conventional and unconventional protein kinase C (PKC) isoforms, facilitating the translocation of PKC from the cytosol to the plasma membrane. The effects of DAG are mimicked by tumor-promoting phorbol esters. DAG is also a precursor for the biosynthesis of prostaglandins, the endocannabinoid 2-arachidonoylglycerol and an activator of a subfamily of TRP-C (Transient Receptor Potential Canonical) cation channels 3, 6, and 7

external resources
NCBI:1269363
REACTOME:R-HSA-114508
PUBMED:17157506
PUBMED:9601053

genes
DAGLA , DGKA , DGKB , DGKG , DGKQ , ITPR1 , ITPR2 , ITPR3 , PRKCD , PRKCE , PRKCH , PRKCQ , TRPC3 , TRPC6 , DGKZ , DGKE , DGKD , DGKI , RASGRP1 , RASGRP2 , MGLL , ABHD12 , TRPC7 , ABHD6 , DGKK , DGKH , DAGLB ,