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description
Activation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium and activation of Protein Kinase C (PKC). Phospholipase C cleaves the phosphodiester bond in PIP2 to form 1,2 Diacylglycerol (DAG) and 1,4,5-inositol trisphosphate (IP3). IP3 opens Ca2+ channels in the platelet dense tubular system, raising intracellular Ca2+ levels. DAG is a second messenger that regulates a family of Ser/Thr kinases consisting of PKC isozymes (Nishizuka 1995). DAG achieves activation of PKC isozymes by increasing their affinity for phospholipid. Most PKC enzymes are also calcium-dependent, so their activation is in synergy with the rise in intracellular Ca2+. Platelets contain several PKC isoforms that can be activated by DAG and/or Ca2+ (Chang 1997)

external resources
NCBI:1269365
REACTOME:R-HSA-76005
PUBMED:8424766

genes
A1BG , A2M , SERPINA3 , ACTN4 , ACTN1 , ACTN2 , AHSG , ALB , ALDOA , ANXA5 , APLP2 , APOA1 , APOH , APP , SERPING1 , CALM1 , CALM2 , CALM3 , CALU , CD9 , CD36 , CD63 , CFL1 , CLU , CTSW , CFD , ECM1 , EGF , F5 , F8 , F13A1 , FGA , FGB , FGG , VEGFD , FLNA , FN1 , GAS6 , HGF , HRG , HSPA5 , IGF1 , IGF2 , ISLR , ITGA2B , ITGB3 , ITIH3 , ITIH4 , KNG1 , LAMP2 , LGALS3BP , ORM1 , ORM2 , SERPINE1 , PCDH7 , PDGFA , PDGFB , PECAM1 , PF4 , PFN1 , SERPINA1 , SERPINA4 , PLG , PLEK , SERPINF2 , PPBP , PPIA , SRGN , PRKCA , PRKCB , PRKCG , PROS1 , PSAP , QSOX1 , RAB27B , RARRES2 , SELP , SELENOP , SOD1 , SPARC , SPP2 , STX4 , STXBP2 , STXBP3 , TF , TGFB1 , TGFB2 , TGFB3 , LEFTY2 , THBS1 , TIMP1 , TIMP3 , TLN1 , TMSB4X , CLEC3B , TTN , TUBA4A , VCL , VEGFA , VEGFB , VEGFC , VWF , MANF , TAGLN2 , PHACTR2 , WDR1 , LHFPL2 , ABCC4 , FAM3C , CAP1 , VTI1B , MAGED2 , MMRN1 , HABP4 , ENDOD1 , BRPF3 , SCG3 , OLA1 , SCCPDH , TEX264 , FAM49B , CYB5R1 , TMX3 , GTPBP2 , TOR4A , CDC37L1 , CHID1 , PCYOX1L , FERMT3 , SYTL4 , CD109 , APOOL , LY6G6F , NHLRC2 , POTEKP ,