description
Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification

external resources
NCBI:83109
KEGG:hsa05213
PUBMED:14747944
PUBMED:11431710
PUBMED:7585656
PUBMED:16508724
PUBMED:15284264
PUBMED:17028294
PUBMED:16248975
PUBMED:15947972

genes
AKT1 , AKT2 , APC , ARAF , BAD , CCND1 , BRAF , CASP9 , CDH1 , CTNNA1 , CTNNA2 , CTNNB1 , EGF , EGFR , ELK1 , ERBB2 , FOXO3 , GRB2 , GSK3B , HRAS , ILK , KRAS , MLH1 , MYC , NRAS , PDPK1 , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , MAPK1 , MAPK3 , MAP2K1 , MAP2K2 , PTEN , RAF1 , SOS1 , SOS2 , TCF7 , TCF7L2 , TP53 , AXIN1 , AXIN2 , PIK3R3 , AKT3 , APC2 , CTNNA3 , LEF1 , TCF7L1 ,