description
The Tie2/Tek receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development and is expressed exclusively on endothelial lineage. Tie2 interacts with a group of ligands belonging to angiopoietin family and undergoes activation.These ligands show opposing actions, angiopoietin 1 and angiopoietin 4 stimulate the Tie2 phosphorylation and angiopoietin 2 inhibits it. Upon tyrosine phosphorylation Tie2 acts as a scaffold for various signaling proteins involved in different signal transduction cascades that can effect survival of endothelium and angiogenic sprout formation

external resources
NCBI:1269374
REACTOME:R-HSA-210993
PUBMED:11566266
PUBMED:11969368
PUBMED:9764820
PUBMED:11191051

genes
ANGPT1 , ANGPT2 , GRB2 , GRB7 , GRB14 , HRAS , KRAS , NRAS , PIK3CA , PIK3CB , PIK3R1 , PIK3R2 , PTPN11 , SHC1 , SOS1 , TEK , DOK2 , ANGPT4 ,