description
Activated epidermal growth factor receptors (EGFR) can stimulate phosphatidylinositol (PI) turnover. Activated EGFR can activate phospholipase C-gamma1 (PLC-gamma1, i.e. PLCG1) which hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). IP3 is instrumental in the release of calcium from intracellular stores and DAG is involved in protein kinase C activation

external resources
NCBI:1269381
REACTOME:R-HSA-212718
PUBMED:1501243

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , GRK2 , CALM1 , CALM2 , CALM3 , CAMK4 , CREB1 , EGF , EGFR , ITPR1 , ITPR2 , ITPR3 , PDE1A , PDE1C , PDE1B , PLCG1 , PRKACA , PRKACB , PRKACG , PRKAR1A , PRKAR1B , PRKAR2A , PRKAR2B , PRKCA , PRKCD , PRKCE , PRKCG , AHCYL1 , ADCY4 ,