description
Activated epidermal growth factor receptors (EGFR) can stimulate phosphatidylinositol (PI) turnover. Activated EGFR can activate phospholipase C-gamma1 (PLC-gamma1, i.e. PLCG1) which hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). IP3 is instrumental in the release of calcium from intracellular stores and DAG is involved in protein kinase C activation
external resources
NCBI:1269381
REACTOME:R-HSA-212718
PUBMED:1501243
genes
ADCY1
,
ADCY2
,
ADCY3
,
ADCY5
,
ADCY6
,
ADCY7
,
ADCY8
,
ADCY9
,
GRK2
,
CALM1
,
CALM2
,
CALM3
,
CAMK4
,
CREB1
,
EGF
,
EGFR
,
ITPR1
,
ITPR2
,
ITPR3
,
PDE1A
,
PDE1C
,
PDE1B
,
PLCG1
,
PRKACA
,
PRKACB
,
PRKACG
,
PRKAR1A
,
PRKAR1B
,
PRKAR2A
,
PRKAR2B
,
PRKCA
,
PRKCD
,
PRKCE
,
PRKCG
,
AHCYL1
,
ADCY4
,
