description
Phospholipase C-gamma (PLC-gamma) is a substrate of the fibroblast growth factor receptor (FGFR) and other receptors with tyrosine kinase activity. It is known that the src homology region 2 (SH2 domain) of PLC-gamma and of other signaling molecules (such as GTPase-activating protein and phosphatidylinositol 3-kinase-associated p85) direct their binding toward autophosphorylated tyrosine residues of the FGFR. Recruitment of PLC-gamma results in its phosphorylation and activation by the receptor. Activated PLC-gamma hydrolyzes phosphatidyl inositol[4,5] P2 to form the second messengers diacylglycerol (DAG) and Ins [1,4,5]P3, which stimulate calcium release and activation of calcium/calmodulin dependent kinases

external resources
NCBI:1269394
REACTOME:R-HSA-5654219
PUBMED:10579907
PUBMED:1656221
PUBMED:15863030

genes
FGF1 , FGF2 , FGF3 , FGF4 , FGF5 , FGF6 , FGF8 , FGF9 , FGF10 , FGFR1 , PLCG1 , FGF23 , FGF17 , KL , FGF20 , FGF22 ,