description
The ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which in turn affects the activity or expression of pro-apoptotic factors, which contribute to protection from apoptosis. AKT activation also blocks the activity of GSK-3b which could lead to additional antiapoptotic signals

external resources
NCBI:1269396
REACTOME:R-HSA-5654689
PUBMED:15863030
PUBMED:11057895
PUBMED:12089343
PUBMED:12558974
PUBMED:10918587

genes
FGF1 , FGF2 , FGF3 , FGF4 , FGF5 , FGF6 , FGF8 , FGF9 , FGF10 , FGFR1 , GAB1 , GRB2 , PIK3CA , PIK3R1 , PTPN11 , FGF23 , FGF17 , KL , FRS2 , FGF20 , FGF22 ,