description
Once activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-mediated inhibition of FRS2-tyrosine phosphorylation and the attenuation of ERK signaling through the action of dual-specificity phosphatases, IL17RD/SEF, Sprouty and Spred proteins. A number of these inhibitors are themselves transcriptional targets of the activated FGFR pathway

external resources
NCBI:1269397
REACTOME:R-HSA-5654726
PUBMED:18452557
PUBMED:11997436
PUBMED:20940169
PUBMED:12815057

genes
BRAF , CBL , FGF1 , FGF2 , FGF3 , FGF4 , FGF5 , FGF6 , FGF8 , FGF9 , FGF10 , FGFR1 , GRB2 , ANOS1 , PPP2CA , PPP2CB , PPP2R1A , MAPK1 , MAPK3 , PTPN11 , RPS27A , SRC , UBA52 , UBB , UBC , FGF23 , MKNK1 , FGF17 , KL , SPRY2 , FRS2 , FGF20 , FGF22 ,