description
The FRS family of scaffolding adaptor proteins has two members, FRS2 (also known as FRS2 alpha) and FRS3 (also known as FRS2beta or SNT-2). Activation of FGFR tyrosine kinase allows FRS proteins to become phosphorylated on tyrosine residues and then bind to the adaptor GRB2 and the tyrosine phosphatase PPTN11/SHP2. Subsequently, PPTN11 activates the RAS-MAP kinase pathway and GRB2 activates the RAS-MAP kinase , PI-3-kinase and ubiquitinations/degradation pathways by binding to SOS, GAB1 and CBL, respectively, via the SH3 domains of GRB2. FRS2 acts as a central mediator in FGF signaling mainly because it induces sustained levels of activation of ERK with ubiquitous expression

external resources
NCBI:1269404
REACTOME:R-HSA-5654700
PUBMED:18452557
PUBMED:11447289
PUBMED:16682955
PUBMED:15863030

genes
FGF1 , FGF2 , FGF3 , FGF4 , FGF5 , FGF6 , FGF7 , FGF8 , FGF9 , FGF10 , FGFR2 , GRB2 , HRAS , KRAS , NRAS , PTPN11 , SOS1 , FGF23 , FGF18 , FGF17 , FGF16 , FRS3 , FRS2 , FGF20 , FGF22 ,