description
Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial syndrome basal cell nevus syndrome (BCNS, or Gorlin syndrome) that predisposes to development of BCC. In addition, there is strong epidemiological and genetic evidence that demonstrates UV exposure as a risk factor of prime importance. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC

external resources
NCBI:83113
KEGG:hsa05217
PUBMED:15948971
PUBMED:15978322
PUBMED:15468170
PUBMED:11276000
PUBMED:11130178
PUBMED:14737121
PUBMED:15270885
PUBMED:16306523
PUBMED:14556242
PUBMED:15656799
PUBMED:16054233
PUBMED:12588368
PUBMED:16881963
PUBMED:11736900

genes
APC , BMP2 , BMP4 , CTNNB1 , DVL1 , DVL2 , DVL3 , FZD2 , GLI1 , GLI2 , GLI3 , GSK3B , PTCH1 , SHH , SMO , TCF7 , TCF7L2 , TP53 , WNT1 , WNT2 , WNT3 , WNT5A , WNT6 , WNT7A , WNT7B , WNT8A , WNT8B , WNT10B , WNT11 , WNT2B , WNT9A , WNT9B , FZD5 , FZD3 , AXIN1 , AXIN2 , FZD1 , FZD4 , FZD6 , FZD7 , FZD8 , FZD9 , PTCH2 , APC2 , FZD10 , STK36 , LEF1 , WNT16 , SUFU , WNT4 , HHIP , WNT10A , WNT5B , TCF7L1 , WNT3A ,