description
Once activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-mediated inhibition of FRS2-tyrosine phosphorylation and the attenuation of ERK signaling through the action of dual-specificity phosphatases, IL17RD/SEF, Sprouty and Spred proteins. A number of these inhibitors are themselves transcriptional targets of the activated FGFR pathway

external resources
NCBI:1269418
REACTOME:R-HSA-5654732
PUBMED:12815057
PUBMED:18452557
PUBMED:11997436
PUBMED:20940169

genes
BRAF , CBL , FGF1 , FGF2 , FGF4 , FGF5 , FGF8 , FGF9 , FGFR3 , GRB2 , PPP2CA , PPP2CB , PPP2R1A , MAPK1 , MAPK3 , PTPN11 , RPS27A , SRC , UBA52 , UBB , UBC , FGF23 , MKNK1 , FGF18 , FGF17 , FGF16 , SPRY2 , FRS2 , FGF20 ,