description
PKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools

external resources
NCBI:1269434
REACTOME:R-HSA-109703

genes
AKT1 , AKT2 , EIF4B , EIF4E , EIF4EBP1 , EIF4G1 , MTOR , PDE3B , PPM1A , PRKAA1 , PRKAA2 , PRKAB1 , PRKAB2 , PRKAG1 , RHEB , RPS6 , RPS6KB1 , STK11 , TSC1 , TSC2 , YWHAB , LAMTOR3 , RRAGB , LAMTOR5 , RRAGA , LAMTOR2 , EEF2K , PRKAG2 , CAB39 , PRKAG3 , LAMTOR1 , STRADB , RPTOR , RRAGD , RRAGC , MLST8 , CAB39L , AKT1S1 , STRADA , LAMTOR4 ,