description
PKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools
external resources
NCBI:1269434
REACTOME:R-HSA-109703
genes
AKT1
,
AKT2
,
EIF4B
,
EIF4E
,
EIF4EBP1
,
EIF4G1
,
MTOR
,
PDE3B
,
PPM1A
,
PRKAA1
,
PRKAA2
,
PRKAB1
,
PRKAB2
,
PRKAG1
,
RHEB
,
RPS6
,
RPS6KB1
,
STK11
,
TSC1
,
TSC2
,
YWHAB
,
LAMTOR3
,
RRAGB
,
LAMTOR5
,
RRAGA
,
LAMTOR2
,
EEF2K
,
PRKAG2
,
CAB39
,
PRKAG3
,
LAMTOR1
,
STRADB
,
RPTOR
,
RRAGD
,
RRAGC
,
MLST8
,
CAB39L
,
AKT1S1
,
STRADA
,
LAMTOR4
,
