description
Now with the complete receptor-ligand dissociation and subsequent degradation of insulin in the endosomal lumen, the endosomally associated protein tyrosine phosphatases (PTPs) complete the receptor dephosphorylation. So too are all the receptor substrates dephosphorylated leading to the collapse of the signalling complexes and signal attenuation

external resources
NCBI:1269441
REACTOME:R-HSA-74749

genes
GRB2 , GRB10 , INS , INSR , IRS1 , MAPK1 , MAPK3 , SHC1 , SOS1 , IRS2 ,