description
Triggered by acidification of the endosome, insulin dissociates from the receptor and is degraded. The receptor is dephosphorylated and re-integrated into the plasma membrane, ready to be activated again by the binding of insulin molecules

external resources
NCBI:1269442
REACTOME:R-HSA-77387

genes
ATP6V1A , ATP6V1B1 , ATP6V1B2 , ATP6V0C , ATP6V1C1 , ATP6V1E1 , ATP6V0B , ATP6V1G2 , ATP6V0A1 , ATP6AP1 , INS , INSR , ATP6V0E1 , ATP6V0D1 , ATP6V1F , ATP6V1G1 , TCIRG1 , ATP6V0A2 , ATP6V0A4 , ATP6V1D , ATP6V1H , ATP6V1E2 , ATP6V1G3 , ATP6V0E2 , ATP6V0D2 , ATP6V1C2 , MIR5010 ,