description
Once bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pro-apoptotic genes, and directly activates the cell death machinery. Only NGF-bound p75NTR is shown here

external resources
NCBI:1269448
REACTOME:R-HSA-193648
PUBMED:12376548

genes
ABR , BAD , ECT2 , FGD1 , MCF2 , NGF , NGFR , MAPK8 , RAC1 , RASGRF2 , ITSN1 , SOS1 , SOS2 , TIAM1 , TRIO , VAV1 , VAV2 , ARHGEF5 , ARHGEF7 , KALRN , ARHGEF1 , ARHGEF2 , ARHGEF6 , MAGED1 , ARHGEF10 , ARHGEF11 , ARHGEF17 , BCL2L11 , NET1 , VAV3 , GNA13 , AKAP13 , ARHGEF15 , ARHGEF9 , MCF2L , ARHGEF12 , ARHGEF18 , NGEF , ARHGEF26 , TIAM2 , AATF , ARHGEF16 , ARHGEF4 , ARHGEF3 , ARHGEF38 , ARHGEF10L , ARHGEF40 , PLEKHG5 , PREX1 , PLEKHG2 , OBSCN , ARHGEF39 , FGD3 , FGD4 , ARHGEF19 , FGD2 , ARHGEF37 , ARHGEF35 , ARHGEF33 ,