description
Once bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pro-apoptotic genes, and directly activates the cell death machinery. Only NGF-bound p75NTR is shown here
external resources
NCBI:1269448
REACTOME:R-HSA-193648
PUBMED:12376548
genes
ABR
,
BAD
,
ECT2
,
FGD1
,
MCF2
,
NGF
,
NGFR
,
MAPK8
,
RAC1
,
RASGRF2
,
ITSN1
,
SOS1
,
SOS2
,
TIAM1
,
TRIO
,
VAV1
,
VAV2
,
ARHGEF5
,
ARHGEF7
,
KALRN
,
ARHGEF1
,
ARHGEF2
,
ARHGEF6
,
MAGED1
,
ARHGEF10
,
ARHGEF11
,
ARHGEF17
,
BCL2L11
,
NET1
,
VAV3
,
GNA13
,
AKAP13
,
ARHGEF15
,
ARHGEF9
,
MCF2L
,
ARHGEF12
,
ARHGEF18
,
NGEF
,
ARHGEF26
,
TIAM2
,
AATF
,
ARHGEF16
,
ARHGEF4
,
ARHGEF3
,
ARHGEF38
,
ARHGEF10L
,
ARHGEF40
,
PLEKHG5
,
PREX1
,
PLEKHG2
,
OBSCN
,
ARHGEF39
,
FGD3
,
FGD4
,
ARHGEF19
,
FGD2
,
ARHGEF37
,
ARHGEF35
,
ARHGEF33
,
