description
NRIF (nuclear receptor-interacting factor) is a DNA binding protein that is essential for p75-mediated apoptosis in retina and sympathetic neurons. Neurotrophin or proneurotrophin binding to p75TR induces nuclear translocation of NRIF, which involves gamma-secretase cleavage of p75NTR ICD (Intra Cellular Domain). Once in the nucleus, NRIF mediates apoptosis, probably by acting as transcription factor
external resources
NCBI:1269449
REACTOME:R-HSA-205043
PUBMED:15721744
genes
NGF
,
NGFR
,
MAPK8
,
PSEN2
,
RPS27A
,
TRAF6
,
UBA52
,
UBB
,
UBC
,
SQSTM1
,
NCSTN
,
ITGB3BP
,
APH1A
,
PSENEN
,
APH1B
,
