description
NRIF (nuclear receptor-interacting factor) is a DNA binding protein that is essential for p75-mediated apoptosis in retina and sympathetic neurons. Neurotrophin or proneurotrophin binding to p75TR induces nuclear translocation of NRIF, which involves gamma-secretase cleavage of p75NTR ICD (Intra Cellular Domain). Once in the nucleus, NRIF mediates apoptosis, probably by acting as transcription factor

external resources
NCBI:1269449
REACTOME:R-HSA-205043
PUBMED:15721744

genes
NGF , NGFR , MAPK8 , PSEN2 , RPS27A , TRAF6 , UBA52 , UBB , UBC , SQSTM1 , NCSTN , ITGB3BP , APH1A , PSENEN , APH1B ,