description
Acute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation program. AML accounts for approximately 80% of all adult leukemias and remains the most common cause of leukemia death. Two major types of genetic events have been described that are crucial for leukemic transformation. A proposed necessary first event is disordered cell growth and upregulation of cell survival genes. The most common of these activating events were observed in the RTK Flt3, in N-Ras and K-Ras, in Kit, and sporadically in other RTKs. Alterations in myeloid transcription factors governing hematopoietic differentiation provide second necessary event for leukemogenesis. Transcription factor fusion proteins such as AML-ETO, PML-RARalpha or PLZF-RARalpha block myeloid cell differentiation by repressing target genes. In other cases, the transcription factors themselves are mutated

external resources
NCBI:83117
KEGG:hsa05221
PUBMED:12951584
PUBMED:12563308
PUBMED:16352814
PUBMED:16236521
PUBMED:16146838
PUBMED:16642045
PUBMED:15625120
PUBMED:11721960
PUBMED:17554387
PUBMED:12468433

genes
AKT1 , AKT2 , ARAF , BAD , CCND1 , BRAF , RUNX1 , RUNX1T1 , CEBPA , CHUK , EIF4EBP1 , FLT3 , MTOR , GRB2 , HRAS , IKBKB , JUP , KIT , KRAS , MYC , NFKB1 , NRAS , PIK3CA , PIK3CB , PIM1 , PIK3CD , PIK3R1 , PIK3R2 , PML , PPARD , MAPK1 , MAPK3 , MAP2K1 , MAP2K2 , RAF1 , RARA , RELA , RPS6KB1 , RPS6KB2 , SOS1 , SOS2 , SPI1 , STAT3 , STAT5A , STAT5B , TCF7 , TCF7L2 , ZBTB16 , PIK3R3 , IKBKG , CCNA1 , AKT3 , PIM2 , LEF1 , TCF7L1 ,