description
Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control

external resources
NCBI:83118
KEGG:hsa05222
PUBMED:12711111
PUBMED:11463388
PUBMED:12741677
PUBMED:11905738
PUBMED:11807782
PUBMED:12379883
PUBMED:12243753
PUBMED:12616528
PUBMED:11720739
PUBMED:15109562
PUBMED:12407699
PUBMED:10944551
PUBMED:16112428
PUBMED:11559746
PUBMED:16064138
PUBMED:11902573

genes
AKT1 , AKT2 , APAF1 , BIRC2 , BIRC3 , XIAP , CCND1 , BCL2 , BCL2L1 , CASP9 , CCNE1 , CDK2 , CDK4 , CDK6 , CDKN1B , CDKN2B , CHUK , CKS1B , CKS2 , COL4A1 , COL4A2 , COL4A3 , COL4A4 , COL4A5 , COL4A6 , E2F1 , E2F2 , E2F3 , FHIT , FN1 , IKBKB , ITGA6 , ITGA2 , ITGA2B , ITGA3 , ITGAV , ITGB1 , LAMA2 , LAMA3 , LAMA4 , LAMA5 , LAMB1 , LAMB2 , LAMB3 , LAMC1 , LAMC2 , MAX , MYC , NFKB1 , NFKBIA , NOS2 , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PTEN , PTGS2 , PTK2 , RARB , RB1 , RELA , RXRA , RXRB , RXRG , SKP2 , TP53 , TRAF1 , TRAF2 , TRAF3 , TRAF5 , TRAF6 , PIK3R3 , IKBKG , PIAS2 , CCNE2 , TRAF4 , AKT3 , LAMC3 , LAMB4 , CYCS , BIRC7 , BIRC8 , LAMA1 ,