description
Neurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS, ocurring from caveolae in the plasma membrane or from clathrin-coated vesicles, and via RAP1, taking place in early endosomes. Whereas RAS activation by NGF is transient, RAP1 activation by NGF is sustained for hours

external resources
NCBI:1269464
REACTOME:R-HSA-187687
PUBMED:10508738

genes
ACTN2 , ANGPT1 , ARAF , ARRB1 , ARRB2 , BRAF , BTC , CALM1 , CALM2 , CALM3 , CAMK2A , CAMK2B , CAMK2D , CAMK2G , CRK , CRKL , MAPK14 , CSF2 , CSF2RA , CSF2RB , CSK , DLG4 , HBEGF , DUSP1 , DUSP2 , DUSP4 , DUSP5 , DUSP6 , DUSP7 , DUSP8 , DUSP9 , EGF , EGFR , ERBB2 , ERBB3 , ERBB4 , EREG , FGA , FGB , FGF1 , FGF2 , FGF3 , FGF4 , FGF5 , FGF6 , FGF7 , FGF8 , FGF9 , FGF10 , FGFR1 , FGFR3 , FGFR2 , FGFR4 , FGG , FN1 , FYN , GDNF , GFRA1 , GFRA2 , GFRA3 , GRB2 , RAPGEF1 , GRIN1 , GRIN2A , GRIN2B , GRIN2C , GRIN2D , HGF , NRG1 , HRAS , IL2 , IL2RA , IL2RB , IL2RG , IL3 , IL3RA , IL5 , IL5RA , IRS1 , ITGA2B , ITGB3 , JAK1 , JAK2 , JAK3 , KIT , KRAS , MARK3 , MET , KITLG , MAP3K11 , NCAM1 , NEFL , NF1 , NGF , NRAS , NRTN , NTRK1 , PEBP1 , PDGFA , PDGFB , PDGFRA , PDGFRB , PHB , PLCG1 , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R5A , PPP2R5B , PPP2R5C , PPP2R5D , PPP2R5E , PPP5C , MAPK1 , MAPK3 , MAPK11 , MAPK13 , MAP2K1 , MAP2K2 , PSPN , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , PTK2 , PTPRA , RAF1 , RALA , RALB , RALGDS , RAP1A , RAP1B , RASA1 , RASA2 , RASGRF1 , RASGRF2 , RET , RIT2 , RIT1 , RPS27A , MAPK12 , SHC1 , SOS1 , SPTA1 , SPTAN1 , SPTB , SPTBN1 , SPTBN2 , SRC , TEK , TLN1 , UBA52 , UBB , UBC , VCL , VWF , YWHAB , MAPKAPK3 , SEM1 , FGF23 , BRAP , RASAL1 , CUL3 , LAMTOR3 , IRS2 , PEA15 , FGF18 , FGF17 , FGF16 , IQGAP1 , SYNGAP1 , KSR1 , ARTN , MAPKAPK2 , KL , RASAL2 , PSMF1 , NRG2 , RAPGEF2 , PSMD6 , FGF19 , RBX1 , RANBP9 , RASGRP1 , AKAP9 , RASA4 , PSME3 , PSMD14 , CNKSR1 , NRG3 , FRS3 , FRS2 , DUSP10 , RASA3 , CNKSR2 , PSME4 , SHC2 , RASGRP3 , FGF20 , FGF22 , LAT , LAMTOR2 , SPTBN5 , SHC3 , APBB1IP , IL17RD , KIDINS220 , SPTBN4 , GFRA4 , RASAL3 , DUSP16 , KBTBD7 , WDR83 , RASGRP4 , PSMB11 , PSMA8 , NRG4 , PAQR3 , KLB , DAB2IP , SPRED1 , SPRED2 , RASGEF1A , KSR2 , SPRED3 , C7orf76 , LOC100506136 , MIR5004 ,