description
The activation of phosphlipase C-gamma (PLC-gamma) and subsequent mobilization of calcium from intracellular stores are essential for neurotrophin secretion. PLC-gamma is activated through the phosphorylation by TrkA receptor kinase and this form hydrolyses PIP2 to generate inositol tris-phosphate (IP3) and diacylglycerol (DAG). IP3 promotes the release of Ca2+ from internal stores and this results in activation of enzymes such as protein kinase C and Ca2+ calmodulin-regulated protein kinases

external resources
NCBI:1269472
REACTOME:R-HSA-167021
PUBMED:12676795
PUBMED:10579907

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , GRK2 , CALM1 , CALM2 , CALM3 , CAMK4 , CREB1 , ITPR1 , ITPR2 , ITPR3 , NGF , NTRK1 , PDE1A , PDE1C , PDE1B , PLCG1 , PRKACA , PRKACB , PRKACG , PRKAR1A , PRKAR1B , PRKAR2A , PRKAR2B , PRKCA , PRKCD , PRKCE , PRKCG , AHCYL1 , ADCY4 ,