description
The activation of phosphlipase C-gamma (PLC-gamma) and subsequent mobilization of calcium from intracellular stores are essential for neurotrophin secretion. PLC-gamma is activated through the phosphorylation by TrkA receptor kinase and this form hydrolyses PIP2 to generate inositol tris-phosphate (IP3) and diacylglycerol (DAG). IP3 promotes the release of Ca2+ from internal stores and this results in activation of enzymes such as protein kinase C and Ca2+ calmodulin-regulated protein kinases
external resources
NCBI:1269472
REACTOME:R-HSA-167021
PUBMED:12676795
PUBMED:10579907
genes
ADCY1
,
ADCY2
,
ADCY3
,
ADCY5
,
ADCY6
,
ADCY7
,
ADCY8
,
ADCY9
,
GRK2
,
CALM1
,
CALM2
,
CALM3
,
CAMK4
,
CREB1
,
ITPR1
,
ITPR2
,
ITPR3
,
NGF
,
NTRK1
,
PDE1A
,
PDE1C
,
PDE1B
,
PLCG1
,
PRKACA
,
PRKACB
,
PRKACG
,
PRKAR1A
,
PRKAR1B
,
PRKAR2A
,
PRKAR2B
,
PRKCA
,
PRKCD
,
PRKCE
,
PRKCG
,
AHCYL1
,
ADCY4
,
