description
The role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of around 100 amino acids that can bind a phosphorylated tyrosine residue. These downstream molecules are activated upon binding to, or phosphorylated by, the receptor kinases intrinsic to PDGF receptors.Some of the dowstream molecules are themselves enzymes, such as phosphatidylinositol 3'-kinase (PI3K), phospholipase C (PLC-gamma), the Src family of tyrosine kinases, the tyrosine phosphatase SHP2, and a GTPase activating protein (GAP) for Ras. Others such as Grb2 are adaptor molecules which link the receptor with downstream catalytic molecules

external resources
NCBI:1269479
REACTOME:R-HSA-186763
PUBMED:10508235
PUBMED:9739761

genes
ACTN2 , ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , GRK2 , AKT1 , AKT2 , ANGPT1 , ARAF , ARRB1 , ARRB2 , BAD , BRAF , BTC , CALM1 , CALM2 , CALM3 , CAMK4 , CAMK2A , CAMK2B , CAMK2D , CAMK2G , CASP9 , CD19 , CD28 , CD80 , CD86 , CDKN1A , CDKN1B , CHUK , CREB1 , CRK , CRKL , CSF2 , CSF2RA , CSF2RB , CSK , DLG4 , HBEGF , DUSP1 , DUSP2 , DUSP4 , DUSP5 , DUSP6 , DUSP7 , DUSP8 , DUSP9 , EGF , EGFR , ERBB2 , ERBB3 , ERBB4 , EREG , FGA , FGB , FGF1 , FGF2 , FGF3 , FGF4 , FGF5 , FGF6 , FGF7 , FGF8 , FGF9 , FGF10 , FGFR1 , FGFR3 , FGFR2 , FGFR4 , FGG , FOXO1 , FOXO3 , FN1 , MTOR , FYN , GAB1 , GDNF , GFRA1 , GFRA2 , GFRA3 , GRB2 , GRB7 , RAPGEF1 , GRIN1 , GRIN2A , GRIN2B , GRIN2C , GRIN2D , GSK3A , GSK3B , HGF , NRG1 , NR4A1 , HRAS , IL2 , IL2RA , IL2RB , IL2RG , IL3 , IL3RA , IL5 , IL5RA , INS , INSR , IRS1 , ITGA2B , ITGB3 , ITPR1 , ITPR2 , ITPR3 , JAK1 , JAK2 , JAK3 , KIT , KRAS , LCK , MARK3 , MDM2 , MET , KITLG , MAP3K11 , FOXO4 , MOV10 , NCAM1 , NCK1 , NEFL , NF1 , NRAS , NRTN , PEBP1 , PDE1A , PDE1C , PDE1B , PDGFA , PDGFB , PDGFRA , PDGFRB , PDPK1 , PHB , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PIP4K2A , PLCG1 , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R5A , PPP2R5B , PPP2R5C , PPP2R5D , PPP2R5E , PPP5C , PRKACA , PRKACB , PRKACG , PRKAR1A , PRKAR1B , PRKAR2A , PRKAR2B , PRKCA , PRKCD , PRKCE , PRKCG , MAPK1 , MAPK3 , MAP2K1 , MAP2K2 , PSPN , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , PTEN , PTK2 , PTPN11 , PTPRA , RAF1 , RAP1A , RAP1B , RASA1 , RASA2 , RASGRF1 , RASGRF2 , RET , RPS6KB2 , RPS27A , SHC1 , SOS1 , SPTA1 , SPTAN1 , SPTB , SPTBN1 , SPTBN2 , SRC , STAT1 , STAT3 , STAT5A , STAT5B , STAT6 , TEK , TLN1 , TP53 , TSC2 , UBA52 , UBB , UBC , VAV1 , VCL , VWF , YWHAB , SEM1 , FGF23 , BRAP , PIP5K1A , PIP5K1B , PIP4K2B , RASAL1 , NCK2 , CUL3 , PIK3R3 , LAMTOR3 , IRS2 , PEA15 , FGF18 , FGF17 , FGF16 , IQGAP1 , SYNGAP1 , KSR1 , IER3 , ARTN , KL , RASAL2 , PSMF1 , NRG2 , BCAR1 , RAPGEF2 , PSMD6 , FGF19 , RBX1 , AKT3 , RANBP9 , RASGRP1 , AKAP9 , RASA4 , PSME3 , PSMD14 , CNKSR1 , NRG3 , AHCYL1 , FRS3 , FRS2 , DUSP10 , RASA3 , CNKSR2 , PHLPP2 , TNRC6B , PSME4 , PHLPP1 , PIP5K1C , SHC2 , RASGRP3 , FGF20 , AGO1 , FGF22 , LAT , AGO2 , TNRC6A , LAMTOR2 , ICOS , TRAT1 , SPTBN5 , SHC3 , APBB1IP , IL17RD , PRR5 , TNRC6C , SPTBN4 , TRIB3 , GFRA4 , MLST8 , RASAL3 , MAPKAP1 , PIP4K2C , DUSP16 , KBTBD7 , WDR83 , AKT1S1 , RASGRP4 , THEM4 , PIK3AP1 , PSMB11 , PSMA8 , NRG4 , PAQR3 , KLB , DAB2IP , SPRED1 , AGO3 , AGO4 , ADCY4 , SPRED2 , RASGEF1A , RICTOR , KSR2 , SPRED3 , C7orf76 , LOC100506136 , MIR5004 ,