description
Asthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and airway inflammation. Inhaled allergens encounter antigen presenting cells (APC) that line the airway. Upon recognition of the antigen and activation by APC, naive T cells differentiate into TH2 cells. Activated TH2 stimulate the formation of IgE by B cells. IgE molecules bind to IgE receptors located on mast cells. The crosslinking of mast-cell-bound IgE by allergens leads to the release of biologically active mediators (histamine, leukotrienes) by means of degranulation and, so, to the immediate symptoms of allergy. Mast cells also release chemotactic factors that contribute to the recruitment of inflammatory cells, particularly eosinophils, whose proliferation and differentiation from bone marrow progenitors is promoted by IL-5. The activation of eosinophils leads to release of toxic granules and oxygen free radicals that lead to tissue damage and promote the development of chronic inflammation

external resources
NCBI:83120
KEGG:hsa05310
PUBMED:11686879
PUBMED:17364144
PUBMED:10811837
PUBMED:11477111
PUBMED:18274559
PUBMED:11172168
PUBMED:18274560
PUBMED:10719286
PUBMED:12093011
PUBMED:17976144
PUBMED:17133123

genes
CD40 , CD40LG , FCER1A , MS4A2 , FCER1G , HLA-DMA , HLA-DMB , HLA-DOA , HLA-DOB , HLA-DPA1 , HLA-DPB1 , HLA-DQA1 , HLA-DQA2 , HLA-DQB1 , HLA-DRA , HLA-DRB1 , HLA-DRB5 , IL3 , IL4 , IL5 , IL9 , IL10 , IL13 , PRG2 , RNASE3 , CCL11 , TNF , EPX ,